Key result
Administration of isoproterenol, ouabain, and calcium demonstrated that both average systolic impedance and myocardial contractility act significantly to alter cardiac output in dogs.
Why the study?
Do average systolic impedance and myocardial contractility determine cardiac output after administration of isoproterenol and ouabain in dogs?
Population
15 dogs (Group I: n=10; Group II: n=5)
Design
Preclinical
Authors
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Supports mechanistic insights into output regulation under inotropic challenge; hypothesis-generating and leaves open translation to clinical settings.
Do average systolic impedance and myocardial contractility determine cardiac output after administration of isoproterenol and ouabain in dogs?
Both average systolic impedance and myocardial contractility independently or jointly alter cardiac output following inotropic stimulation.
Liedtke et al. (1972) studied this question. Isoproterenol, ouabain, and calcium was evaluated on Cardiac output. Administration of isoproterenol, ouabain, and calcium demonstrated that both average systolic impedance and myocardial contractility act significantly to alter cardiac output in dogs.
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