Key result
Ouabain augments myocardial contractility, increasing shortening velocity by ~77% without increasing cardiac output.
Why the study?
Does ouabain (0.01 mg/kg) augment myocardial contractility in patients who have undergone corrective cardiac operations?
Population
6 patients who had previously undergone corrective cardiac operations, and isolated papillary muscles…
Design
Case_series
Authors
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Caution against expecting output gains from ouabain in stable post-surgical patients; leaves open its role in euvolemic states.
Does ouabain (0.01 mg/kg) augment myocardial contractility in patients who have undergone corrective cardiac operations?
Digitalis glycosides fundamentally augment the contractile state of the heart, but this does not translate to increased cardiac output in the absence of heart failure.
Sonnenblick et al. (1966) studied Prior corrective cardiac operations (n=6). Ouabain was evaluated on Ventricular force-velocity relations (velocity of shortening and intraventricular pressure). Ouabain administration augmented myocardial contractility, increasing velocity of shortening by an average of 77±5% and intraventricular pressure by 23±6%, without increasing cardiac output.
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