Key result
Historical review of digitalis highlights its major action as the augmentation of the force of myocardial contraction, which was initially overlooked by 19th-century investigators.
Design
Review
Authors
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Alerts clinicians to digitalis inotropy in select cases; leaves open its reevaluation amid modern HF therapies.
Provides a historical overview of the understanding of digitalis and its primary mechanism of action on myocardial contraction.
Smith et al. (1973) conducted a review in Heart failure. Digitalis was evaluated. Historical review of digitalis highlights its major action as the augmentation of the force of myocardial contraction, which was initially overlooked by 19th-century investigators.
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