Why the study?
Does ouabain alter hemodynamics and contractility in the nonfailing heart of the dog?
Population
Dogs with a complete circulatory system and nonfailing heart
Design
Preclinical
Authors
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No immediate human application; leaves open translation of ouabain's dual effects to failing hearts.
Does ouabain alter hemodynamics and contractility in the nonfailing heart of the dog?
In the normal dog, ouabain exerts both a direct cardiac stimulant action and a peripheral action that decreases venous return.
Cotten et al. (1957) studied this question.
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