Key result
Ouabain caused a distinct elevation in coronary and systemic resistances with no change in cardiac output in conscious dogs, whereas in the anesthetized state it reduced cardiac output.
Why the study?
Does ouabain alter coronary and systemic dynamics differently in conscious versus anesthetized dogs?
Population
12 dogs with Doppler flow transducers on the ascending aorta and left circumflex coronary artery and…
Comparison
Ouabain (G-strophanthin) 20 µg/kg vs Baseline and comparison between conscious and…
Design
Preclinical
Follow-up
30 minutes
Authors
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Anesthesia confounds ouabain hemodynamics in dogs; supports prioritizing conscious models in cardiovascular research.
Does ouabain alter coronary and systemic dynamics differently in conscious versus anesthetized dogs?
The hemodynamic effects of ouabain differ significantly depending on whether the animal is conscious or anesthetized, highlighting the importance of conscious animal models in cardiovascular pharmacology.
Vatner et al. (1971) studied this question. Ouabain (G-strophanthin) vs. Baseline (control) and anesthetized state was evaluated on Coronary and systemic dynamics (heart rate, arterial pressure, cardiac output, coronary blood flow, and resistances). Ouabain caused a distinct elevation in coronary and systemic resistances with no change in cardiac output in conscious dogs, whereas in the anesthetized state it reduced cardiac output.
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