What question did this study set out to answer?

To compare the inotropic, hemodynamic, and electrophysiological cardiovascular effects of proscillaridin and ouabain in an anaesthetised canine model.

August 1, 1973Australian and New Zealand Journal of Medicine

A Comparison of the Cardiovascular Effects of Proscillaridin and Ouabain in Anaesthetised Dogs

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Why the study?

Does proscillaridin compared to ouabain alter cardiovascular hemodynamics and contractility in anaesthetised dogs?

Population

Anaesthetised dogs

Comparison

Proscillaridin (20, erg/kg) vs Ouabain (20, erg/kg)

Design

Preclinical

Follow-up

60 minutes

Authors

JAJames A. AngusVascular / Pulmonary Vascular DRD. RichmondLeeds General Infirmary LCL. B. CobbinThe University of Sydney

Discussion

Member takes

Implication

Does not support clinical translation; hypothesis-generating for differential glycoside effects in humans.

Key Points

To compare the inotropic, hemodynamic, and electrophysiological cardiovascular effects of proscillaridin and ouabain in an anaesthetised canine model.
Administered 20 µg/kg of either proscillaridin or ouabain to anaesthetised dogs.
Evaluated myocardial contractility, systemic arterial blood pressure, heart rate, PR interval, and atrioventricular (AV) conduction during atrial pacing.
Both glycosides produced equivalent positive inotropic effects, generating a peak increase in myocardial contractility of approximately 20% at 20 to 30 minutes post-administration that persisted for an additional 30 minutes.
Ouabain induced approximately twice the bradycardia observed with proscillaridin.
Both drugs produced transient initial increases in systemic arterial blood pressure, which declined below baseline after 30 minutes with ouabain and at a slower rate with proscillaridin, with neither drug significantly affecting PR interval or AV conduction.

Structured PICO

Does proscillaridin compared to ouabain alter cardiovascular hemodynamics and contractility in anaesthetised dogs?

Population

Anaesthetised dogs

Intervention

Proscillaridin (20, erg/kg)

Comparator

Ouabain (20, erg/kg)

Outcome

Myocardial contractilitysurrogate

Proscillaridin and ouabain produce similar positive inotropic effects in an anaesthetised dog model, though ouabain induces more pronounced bradycardia.

Cite This Study

Angus et al. (1973) studied this question.

synapsesocial.com/papers/6a70a2efa528af2d65c3a748 https://doi.org/10.1111/j.1445-5994.1973.tb03114.x

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A Comparison of the Cardiovascular Effects of Proscillaridin and Ouabain in Anaesthetised Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

A Comparison of the Cardiovascular Effects of Proscillaridin and Ouabain in Anaesthetised Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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