June 1, 1972Circulation ResearchOpen Access

Effects of Lidocaine, Propranolol, and Sotalol on Ouabain-lnduced Changes in Transmembrane Potential of Canine Purkinje Fibers

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Population

Isolated canine papillary muscle-false tendon preparations

Comparison

Lidocaine, propranolol, or sotalol applied… vs Ouabain exposure alone or comparison between the…

Design

Preclinical

Authors

BKBARRY J. KOERPELUniversity of Wisconsin–Madison LDLarry D. DavisSanofi (United States)

Discussion

Member takes

Implication

Supports phase-4 depolarization as arrhythmia target in digitalis toxicity; leaves open clinical translation pending human studies.

Structured PICO

Population

Isolated canine papillary muscle-false tendon preparations

Intervention

Lidocaine (3.7 x 10^-5 M), propranolol (2.1 x 10^-5 M), or sotalol (3.2 x 10^-4 M) applied before or after exposure to ouabain (2.1 x 10^-7 M)

Comparator

Ouabain exposure alone (implied control) or comparison between the three drugs

Outcome

Changes in transmembrane potential of Purkinje fibers (specifically phase-4 depolarization)surrogate

Lidocaine and propranolol suppress ouabain-induced enhanced phase-4 depolarization in canine Purkinje fibers, supporting this mechanism in digitalis-induced ventricular arrhythmias.

Cite This Study

KOERPEL et al. (1972) studied this question.

synapsesocial.com/papers/6a866318fb63d0a2a03a7204 https://doi.org/10.1161/01.res.30.6.681

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Effects of Lidocaine, Propranolol, and Sotalol on Ouabain-lnduced Changes in Transmembrane Potential of Canine Purkinje Fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of Lidocaine, Propranolol, and Sotalol on Ouabain-lnduced Changes in Transmembrane Potential of Canine Purkinje Fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider