Why the study?
Do lidocaine, l-chlorpheniramine, and bepridil affect automaticity and delayed afterdepolarizations in normal and ouabain-intoxicated canine Purkinje fibers?
Population
Normal and ouabain-intoxicated canine Purkinje fibers
Design
Preclinical
Authors
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These canine Purkinje fiber findings should not change practice; leaves open selective DAD suppression as a therapeutic target in digitalis toxicity.
Do lidocaine, l-chlorpheniramine, and bepridil affect automaticity and delayed afterdepolarizations in normal and ouabain-intoxicated canine Purkinje fibers?
Lidocaine and bepridil, but not l-chlorpheniramine, reduce ouabain-induced delayed afterdepolarizations in canine Purkinje fibers, with bepridil exhibiting cycle-length dependent effects.
Kane et al. (1983) studied this question.
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