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March 1, 1976Cardiovascular Research

Intracellular electrophysiological alterations in canine cardiac conducting tissue induced by aprindine and lignocaine

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Authors

MSMitchell I. SteinbergBeiersdorf (Germany)KGKalman GreenspanSidney & Lois Eskenazi Hospital

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Implication

Hypothesis-generating for use-dependent Na-channel block; leaves open translation to clinical antiarrhythmic selection.

Key Points

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Cite This Study

Steinberg et al. (1976) studied this question.

synapsesocial.com/papers/6a710e81e5469ee92be1afd4https://doi.org/10.1093/cvr/10.2.236
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electrophysiological Actions of Lidocaine on Canine Ventricular Muscle and Purkinje Fibers1969 · 154 citations
  2. 2Effect of lidocaine on the electrophysiological properties of ventricular muscle and Purkinje fibers1970 · 269 citations
  3. 3Actions of lidocaine on transmembrane potentials of subendocardial Purkinje fibers surviving in infarcted canine hearts.1978 · 47 citations
  4. 4Electrophysiological Effects of Lidocaine, l-Chlorpheniramine, and Bepridil on Normal and Ouabain-Intoxicated Canine Purkinje Fibers1983 · 13 citations
  5. 5MECHANISMS OF LIDOCAINE ACTIONS ON NORMAL AND ABNORMAL RHYTHMS IN CANINE CARDIAC TISSUES IN VIVO AND IN VITRO1991 · 8 citations