Key result
Sustained shortening of the cycle length increased the slope of diastolic depolarization in ouabain-treated canine Purkinje fibers, while sustained lengthening had the opposite effect.
Why the study?
Does changing cycle length alter diastolic depolarization produced by ouabain in canine Purkinje fibers?
Population
Isolated canine papillary muscle-false tendon tissue preparations
Comparison
Changes in cycle length after treatment with… vs Baseline cycle length or opposite changes in…
Design
Preclinical
Authors
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Alerts to potential proarrhythmic ouabain effects at short cycle lengths; extends mechanistic insights but leaves human translation open.
Does changing cycle length alter diastolic depolarization produced by ouabain in canine Purkinje fibers?
Shortening cycle length enhances ouabain-induced diastolic depolarization in canine Purkinje fibers, suggesting a mechanism for digitalis-induced ventricular arrhythmias.
Larry D. Davis (1973) studied this question. Ouabain and changes in cycle length was evaluated on Slope of diastolic depolarization of Purkinje fibers. Sustained shortening of the cycle length increased the slope of diastolic depolarization in ouabain-treated canine Purkinje fibers, while sustained lengthening had the opposite effect.
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