Key result
Maximum diastolic potentials in Purkinje fibers from 1-day-old puppies (-78.0 mV) were significantly less negative than those from adult dogs (-84.2 mV), and neonatal fibers exposed to ouabain depolarized less.
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Suggests age-dependent electrophysiological differences may protect neonates from digitalis.
Absolute Event Rate: -78% vs -84.2%
Gaum et al. (2017) studied this question. Ouabain exposure and young age vs. Adult dogs / unexposed fibers was evaluated on Maximum diastolic potentials. Maximum diastolic potentials in Purkinje fibers from 1-day-old puppies (-78.0 mV) were significantly less negative than those from adult dogs (-84.2 mV), and neonatal fibers exposed to ouabain depolarized less.
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