Key result
Lidocaine reduces Vmax more profoundly and rapidly in adult versus young canine Purkinje fibers.
Authors
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May inform age-specific lidocaine dosing; leaves open translation from canine Purkinje fibers to human arrhythmias.
Morikawa et al. (1984) studied this question. Lidocaine vs. Young vs adult fibers was evaluated on Transmembrane potential properties (Vmax, membrane responsiveness, steady state recovery kinetics). Lidocaine reduced Vmax of adult canine Purkinje fibers to a greater extent and with more rapid onset of tonic and use-dependent block compared to young fibers.
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