Key result
Lidocaine had a significantly greater depressant effect on conduction and accelerated repolarization in adult dogs compared to young dogs, whereas quinidine prolonged repolarization more in the young.
Why the study?
Does the developmental stage (adult vs young) alter the electrophysiologic effects of intravenous lidocaine and quinidine in the canine heart?
Population
Intact canine heart model (adult vs young dogs)
Comparison
Intravenous lidocaine and quinidine vs Comparison between adult and young dogs
Design
Preclinical
Authors
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Age may influence lidocaine's use-dependent effects; leaves open translation to human pediatric dosing.
Does the developmental stage (adult vs young) alter the electrophysiologic effects of intravenous lidocaine and quinidine in the canine heart?
The electrophysiologic effects of antiarrhythmic drugs differ significantly between adult and young hearts due to developmental changes in cellular electrophysiology, drug metabolism, and protein binding.
Morikawa et al. (1987) studied this question. Lidocaine and quinidine vs. Adult vs young dogs was evaluated on Use-dependent effects on intraventricular conduction and repolarization. Lidocaine had a significantly greater depressant effect on conduction and accelerated repolarization in adult dogs compared to young dogs, whereas quinidine prolonged repolarization more in the young.
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