January 1, 1981Circulation ResearchOpen Access

pH-dependent electrophysiological effects of quinidine and lidocaine on canine cardiac purkinje fibers.

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Why the study?

Does extracellular pH modify the electrophysiological effects of quinidine and lidocaine in canine cardiac Purkinje fibers?

Structured PICO

Does extracellular pH modify the electrophysiological effects of quinidine and lidocaine in canine cardiac Purkinje fibers?

Population

Canine cardiac Purkinje fibers

Intervention

Lidocaine (6 x 10(-6) to 1.5 x 10(-5) M) and Quinidine (6 x 10(-6) to 1.5 x 10(-5) M) at acidic pH (6.9)

Comparator

Same concentrations of lidocaine and quinidine at normal pH (7.3), and acidosis alone

Outcome

Electrophysiological parameters including resting potential, action potential amplitude, and Vmaxsurrogate

Extracellular acidosis significantly exacerbates the depressant electrophysiological effects of antiarrhythmic agents like quinidine and lidocaine on cardiac Purkinje fibers.

Discussion

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Implication

Acidosis may potentiate class I antiarrhythmic effects in ischemic tissue; hypothesis-generating for pH-targeted strategies.

Cite This Study

Nattel et al. (1981) studied this question.

synapsesocial.com/papers/6a209e9e239b4646016d8deb https://doi.org/10.1161/01.res.48.1.55

View Full Paper

Ask AI

Bookmark

pH-dependent electrophysiological effects of quinidine and lidocaine on canine cardiac purkinje fibers.

Structured PICO

Discussion

Implication

Cite This Study

pH-dependent electrophysiological effects of quinidine and lidocaine on canine cardiac purkinje fibers.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider