Population
Purkinje fibers from normal beagles of five age groups: 19.1 +/- 0.8, 63.7 +/- 2.6, 88.3 +/- 1.9, 107.2 +/…
Comparison
Superfusion with slow channel blocker AHR-2666… vs Comparison across different age groups
Design
Preclinical
Authors
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Does not support changes in clinical practice; leaves open whether calcium current alterations drive age-related repolarization shifts in humans.
This preclinical study demonstrates that aging alters Purkinje fiber repolarization in dogs, likely due to changes in slow inward calcium currents.
Rosen et al. (1978) studied this question.
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