January 1, 1982AJP Heart and Circulatory Physiology

Comparative response of the developing canine myocardium to inotropic agents

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Population

Isolated dog ventricular muscle strips obtained from dogs of three age groups: 2 day, 4 wk, and adult

Comparison

Inotropic agents and electrical stimulation vs Comparison across age groups and baseline control

Design

Preclinical

Authors

IPI. S. ParkUlsan College LML. H. Michael DDDavid J. DriscollChildren's Hospital of Wisconsin

Discussion

Member takes

Overview

Should not change pediatric inotrope use; extends canine maturation data but leaves human translation open.

Structured PICO

Population

Isolated dog ventricular muscle strips obtained from dogs of three age groups: 2 day, 4 wk, and adult

Intervention

Inotropic agents (isoproterenol, calcium) and electrical stimulation (single premature extra stimulus, sustained paired stimulation)

Comparator

Comparison across age groups and baseline control

Outcome

Active tension (AT) and maximum rate of contraction and relaxation (+dT/dt, -dT/dt)surrogate

The study demonstrates significant developmental changes in canine myocardial contractile responses to inotropic agents and electrical stimulation, suggesting maturation of membrane systems.

Cite This Study

Park et al. (1982) studied this question.

synapsesocial.com/papers/6a95cea540a936f2a65143cd https://doi.org/10.1152/ajpheart.1982.242.1.h13

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January 1, 1982AJP Heart and Circulatory Physiology

Comparative response of the developing canine myocardium to inotropic agents

View Full Paper

Ask AI

Bookmark

Population

Isolated dog ventricular muscle strips obtained from dogs of three age groups: 2 day, 4 wk, and adult

Comparison

Inotropic agents and electrical stimulation vs Comparison across age groups and baseline control

Design

Preclinical

Authors

IPI. S. ParkUlsan College LML. H. Michael DDDavid J. DriscollChildren's Hospital of Wisconsin

Discussion

Member takes

Overview

Should not change pediatric inotrope use; extends canine maturation data but leaves human translation open.

Structured PICO

Population

Isolated dog ventricular muscle strips obtained from dogs of three age groups: 2 day, 4 wk, and adult

Intervention

Inotropic agents (isoproterenol, calcium) and electrical stimulation (single premature extra stimulus, sustained paired stimulation)

Comparator

Comparison across age groups and baseline control

Outcome

Active tension (AT) and maximum rate of contraction and relaxation (+dT/dt, -dT/dt)surrogate

The study demonstrates significant developmental changes in canine myocardial contractile responses to inotropic agents and electrical stimulation, suggesting maturation of membrane systems.

Cite This Study

Park et al. (1982) studied this question.

synapsesocial.com/papers/6a95cea540a936f2a65143cd https://doi.org/10.1152/ajpheart.1982.242.1.h13

Also Consider

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