Why the study?
Does acute administration of ouabain affect hemodynamics differently in patients with valvular aortic stenosis versus idiopathic hypertrophic subaortic stenosis?
Population
10 patients (6 with valvular aortic stenosis and 4 with idiopathic hypertrophic subaortic stenosis)
Design
Case_series
Follow-up
Acute
Authors
Discussion
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Member takes
Implication
Should not change practice in aortic stenosis; hypothesis-generating for differential ouabain responses by stenosis subtype.
Structured PICO
Does acute administration of ouabain affect hemodynamics differently in patients with valvular aortic stenosis versus idiopathic hypertrophic subaortic stenosis?
P
Population
10 patients (6 with valvular aortic stenosis and 4 with idiopathic hypertrophic subaortic stenosis)
I
Intervention
Ouabain 0.50 to 0.75 mg (acute administration)
O
Outcome
Acute hemodynamic effects including left atrial pressure, left ventricular pressure, cardiac output, and systolic pressure gradientsurrogate
Ouabain improves or maintains hemodynamics in valvular aortic stenosis but worsens outflow obstruction and filling pressures in idiopathic hypertrophic subaortic stenosis.
Cite This Study
Braunwald et al. (1962) studied this question.