Key result
Ouabain and digitalis glycosides have distinct mechanisms of action, challenging the dogma that all cardiotonic steroids work solely via partial inhibition of the Na-K-ATPase.
Ouabain and digitalis glycosides have distinct mechanisms of action, challenging the dogma that all cardiotonic steroids work solely via Na-K-ATPase inhibition.
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Questions unified Na-K-ATPase model for cardiotonic steroids; leaves open ouabain-specific pathways for targeted study.
Hauke Fuerstenwerth (2011) conducted a review in Heart diseases. Ouabain vs. Digitalis glycosides (digoxin and digitoxin) was evaluated. Ouabain and digitalis glycosides have distinct mechanisms of action, challenging the dogma that all cardiotonic steroids work solely via partial inhibition of the Na-K-ATPase.
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