Why the study?
Does ouabain attenuate cardiotoxicity induced by other cardiac steroids like digoxin and bufalin in guinea pig models?
Population
Isolated heart muscle preparations and an in vivo model of cardiotoxicity in anaesthetized guinea pigs
Comparison
Ouabain at a low dose (91 ng.kg.h) or wortmannin… vs Digoxin (500 microg.kg(-1).h(-1)) or bufalin alone
Design
Preclinical
Authors
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Should not inform clinical digoxin management; leaves open dose-dependent interactions among cardiac steroids in vivo.
Does ouabain attenuate cardiotoxicity induced by other cardiac steroids like digoxin and bufalin in guinea pig models?
Low-dose ouabain attenuates digoxin- and bufalin-induced cardiotoxicity in guinea pig models, suggesting a potential mechanism to increase the therapeutic window of cardiac steroids.
Nesher et al. (2010) studied this question.
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