Key result
A subinotropic dose of ouabain (50 µg/kg/day) prevented pressure overload-induced cardiac hypertrophy and improved cardiac function in wild-type mice, but not in mice deficient in cardiac PI3Kα.
Why the study?
Does low-dose ouabain prevent pressure overload-induced cardiac remodeling in mice?
Does low-dose ouabain prevent pressure overload-induced cardiac remodeling in mice?
p-value: p=<0.05
Subinotropic doses of ouabain prevent pressure overload-induced cardiac remodeling in mice through selective activation of PI3Kα.
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Low-dose ouabain may attenuate remodeling via PI3Kα in mice; leaves open translation to human heart failure.
Wu et al. (2015) studied Cardiac hypertrophy and heart failure. Ouabain vs. Vehicle / TAC without ouabain was evaluated on Cardiac hypertrophy and function (Fractional shortening, wall thickness) (p=<0.05). A subinotropic dose of ouabain (50 µg/kg/day) prevented pressure overload-induced cardiac hypertrophy and improved cardiac function in wild-type mice, but not in mice deficient in cardiac PI3Kα.
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