Key result
Sodium channel-modulating inotropes lower the ouabain toxicity threshold by ~50% in atrial tissue.
Why the study?
The interaction between positive inotropic sodium channel modulators and ouabain toxicity in cardiac tissue was investigated to understand potential risks of digitalis toxicity.
Population
Isolated guinea pig atria
Comparison
DPI 201-106, BDF 9148, and veratridine exposure vs no exposure with ouabain
Design
Experimental study on isolated cardiac tissue
Authors
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May potentiate glycoside toxicity in vitro; hypothesis-generating and should not yet change practice.
Herzig et al. (1991) studied this question. DPI 201-106, BDF 9148, and veratridine was evaluated on Threshold ouabain concentration to induce toxicity and specific equilibrium [3H]ouabain binding. Positive inotropic drugs acting as sodium channel modulators lowered the threshold ouabain concentration to induce toxicity by a factor of 2 in isolated guinea pig atria.
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