June 1, 1979British Journal of PharmacologyOpen Access

Stimulation and Inhibition of the Sodium Pump by Cardioactive Steroids in Relation to Their Binding Sites and Their Inotropic Effect on Guinea‐pig Isolated Atria

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Population

Guinea-pig isolated left atria stimulated at 3.3 Hz

Comparison

Ouabain, ouabagenin, and dihydroouabain at… vs Untreated atria and varying KCl concentrations

Design

Preclinical

Authors

JGJ Ghysel-BurtonUCLouvain TGThéophile GodfraindUCLouvain

Discussion

Member takes

Implication

Does not support altering glycoside use in patients; leaves open dual binding sites as inotropic mechanism in humans.

Structured PICO

Population

Guinea-pig isolated left atria stimulated at 3.3 Hz

Intervention

Ouabain, ouabagenin, and dihydroouabain at varying concentrations

Comparator

Untreated atria and varying KCl concentrations (2.7 to 12 mM)

Outcome

Contractility (inotropic effect), ionic content (Na and K), and specific binding of ouabainsurrogate

The study demonstrates two specific binding sites for ouabain in guinea-pig atria, suggesting that Na pump inhibition is not the sole mechanism for the positive inotropic effect of cardiac glycosides.

Cite This Study

Ghysel-Burton et al. (1979) studied this question.

synapsesocial.com/papers/6a71a42a8031ec7bb1dd0e3a https://doi.org/10.1111/j.1476-5381.1979.tb13662.x

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Stimulation and Inhibition of the Sodium Pump by Cardioactive Steroids in Relation to Their Binding Sites and Their Inotropic Effect on Guinea‐pig Isolated Atria

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Stimulation and Inhibition of the Sodium Pump by Cardioactive Steroids in Relation to Their Binding Sites and Their Inotropic Effect on Guinea‐pig Isolated Atria

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider