Key result
Stimulation frequency linearly increases guinea-pig ventricular sodium pump activity above a ~15% resting baseline.
Why the study?
The relationship between [3H]ouabain binding curves and sodium pump activity at different stimulation frequencies in guinea-pig ventricular myocardium was unclear.
Population
Isolated electrically stimulated ventricular strips of guinea-pig hearts
Comparison
Different ouabain concentrations and stimulation frequencies vs resting preparations
Design
Preclinical experimental study with mathematical modeling
Authors
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Guinea-pig ventricular data indicate frequency-dependent sodium pump activity; leaves open translation to human myocardium and clinical relevance.
The study demonstrates that [3H]ouabain binding can be used to measure steady-state sodium pump activity, which increases linearly with stimulation frequency in guinea-pig ventricular myocardium.
Herzig et al. (1988) studied this question. [3H]ouabain and electrical stimulation was evaluated on Sodium pump activity and [3H]ouabain binding. In guinea-pig ventricular preparations, sodium pump activity is a linear function of stimulation frequency, with resting activity amounting to about 15% of maximum activity.
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