Why the study?
Do class I antiarrhythmic drugs bind to the same receptor sites as digitalis glycosides on the myocardial Na+-K+ ATPase in guinea pig heart microsomal preparations?
Population
Guinea pig heart microsomal preparations
Design
Preclinical
Authors
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May contribute to arrhythmogenic effects via shared sites; hypothesis-generating in animal models and leaves clinical relevance open.
Do class I antiarrhythmic drugs bind to the same receptor sites as digitalis glycosides on the myocardial Na+-K+ ATPase in guinea pig heart microsomal preparations?
Class I antiarrhythmic drugs interact with the same or similar receptor sites as ouabain on the Na+-K+ ATPase, which may contribute to their inhibitory and arrhythmogenic effects.
Almotrefi et al. (1999) studied this question.
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