November 12, 2007Archives of Internal Medicine
Implantable Cardioverter Defibrillators and Quality of LifeResults From the Defibrillators in Nonischemic Cardiomyopathy Treatment Evaluation Study
Key result
Implantable cardioverter defibrillators did not significantly affect overall health-related quality of life, though each shock reduced the mental component score by 1.0 ± 0.5 points (P=0.04).
Why the study?
Does implantable cardioverter defibrillator placement affect health-related quality of life in patients with nonischemic cardiomyopathy and LVEF ≤35%?
Population
n=458 patients with nonischemic cardiomyopathy, an ejection fraction of 35% or less, and either nonsustained…
Comparison
Implantable cardioverter defibrillator (ICD) vs Standard medical therapy
Design
RCT, Randomized to an ICD or standard medical therapy
Follow-up
Throughout the trial
Authors
Discussion
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Member takes
Implication
Reassures on overall QoL with ICDs in nonischemic cardiomyopathy; extends DEFINITE mortality benefit without major QoL trade-off.
Study Design
Type
RCT (n=458)
Randomization
Randomized
Structured PICO
Does implantable cardioverter defibrillator placement affect health-related quality of life in patients with nonischemic cardiomyopathy and LVEF ≤35%?
P
Population
n=458 patients with nonischemic cardiomyopathy, an ejection fraction of 35% or less, and either nonsustained ventricular tachycardia or 10 or more premature ventricular depolarizations per hour
I
Intervention
Implantable cardioverter defibrillator (ICD)
C
Comparator
Standard medical therapy
O
Outcome
Health-related quality of life (HRQL) measured by the 12-Item Medical Outcomes Short-Form Health Survey and the Minnesota Living with Heart Failure Questionnairepatient reported
ICD implantation does not significantly affect overall health-related quality of life in patients with nonischemic cardiomyopathy, though experiencing multiple shocks is associated with a decline in emotional and mental well-being.
Cite This Study
Rod Passman (2007) conducted an RCT in Nonischemic cardiomyopathy (n=458). Implantable cardioverter defibrillator (ICD) vs. Standard medical therapy was evaluated on Health-related quality of life (HRQL). Implantable cardioverter defibrillators did not significantly affect overall health-related quality of life, though each shock reduced the mental component score by 1.0 ± 0.5 points (P=0.04).