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Shows asiaticoside reduces mesothelial cell senescence in peritoneal fibrosis, suggesting potential treatment options.
• Peritoneal mesothelial cells consistently communicated strongly with macrophages. • Mesothelial cell senescence has a key role in the development of peritoneal fibrosis. • Reduced IGF1 secretion from Mrc1 + macrophages drove mesothelial cells senescence. • Asiaticoside inhibited mesothelial cell senescence via the macrophage/IGF1 axis.
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You et al. (2026) studied this question.
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