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May 26, 20260 citationsOpen Access

Multi-Epitope Vaccine Inducing Immune Responses Against Crimean-Congo Hemorrhagic Fever Virus...

Multi-epitope vaccine eliciting robust immune responses against diverse Crimean-Congo Hemorrhagic Fever virus strains targeting the glycoprotein and RNA polymerase: An Immunoinformatics-driven approach

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Authors

VBVismay BidwaikSDSutapa DasBDBudheswar Dehury

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Overview

Immunoinformatics-driven approach reveals potential vaccines against diverse virus strains, enhancing future research.

Key Points

  • The aim is to develop a multi-epitope vaccine that targets glycoprotein and RNA polymerase of the Crimean-Congo Hemorrhagic Fever virus.
  • Utilized immunoinformatics to design multi-epitope vaccine candidates.
  • Conducted molecular dynamics simulations with GROMACS version 2024.4 using CHARMM36 force field.
  • Generated and analyzed structural models and simulation files for Vaccine A and Vaccine B.
  • Produced predicted structures of Vaccine A and Vaccine B with favorable stability in molecular dynamics simulations.
  • Vaccine B showed robust interaction with TLR3 and TLR4 complexes, indicating enhanced immune response potential.
  • Data provides a foundation for further computational analysis of vaccine efficacy and receptor interactions.
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Cite This Study

Bidwaik et al. (2025) studied this question.

synapsesocial.com/papers/6a153a2eb5d9c58d83e8d068https://doi.org/10.5281/zenodo.20116937
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