What question did this study set out to answer?

To confirm the chemical structure of mature Staphylococcus aureus AgrD autoinducing peptides and define the structural features required for agr activation and inhibition.

February 16, 1999Proceedings of the National Academy of SciencesOpen Access

Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence

View Full Paper

Ask AI

Bookmark

To confirm the chemical structure of mature Staphylococcus aureus AgrD autoinducing peptides and define the structural features required for agr activation and inhibition.
Chemically synthesized mature AgrD autoinducing peptides containing a cyclic thiol ester (thiolactone) structure.
Assessed synthetic peptide biological activity and structure-activity relationships using in vitro assays and an in vivo mouse protection test.
Synthetic peptide analysis confirmed that the mature AgrD autoinducing peptide possesses a thiolactone ring structure that is strictly essential for full biological activity.
Synthetic AgrD thiolactone peptides displayed potent biological efficacy in vivo in a mouse protection model.
Structure-activity profiling established distinct peptide motifs responsible for self-activation versus cross-strain inhibition, supporting an activation mechanism mediated by AgrC receptor acylation.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Preclinical study reveals that a cyclic thiolactone structure drives AgrD peptide activity in Staphylococcus aureus, indicating receptor acylation regulates bacterial virulence response.

Cite This Study

Mayville et al. (1999) studied this question.

synapsesocial.com/papers/6a153a5fa2352da347821977 https://doi.org/10.1073/pnas.96.4.1218

View Full Paper

Ask AI

Bookmark

Implication

Preclinical study reveals that a cyclic thiolactone structure drives AgrD peptide activity in Staphylococcus aureus, indicating receptor acylation regulates bacterial virulence response.

Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence

Key Points

Discussion

Implication

Cite This Study

Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider