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May 26, 2026Premier Journal of ImmunologyOpen Access

Engineering Natural Killer Cells for Cancer Immunotherapy: Advances, Challenges, and Future Perspectives

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Authors

SSSumit Sharma

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Overview

Review discusses engineering natural killer cells to enhance cancer treatment efficacy, highlighting implications for future therapies.

Key Points

  • To explore advancements and challenges in engineering natural killer (NK) cells for cancer immunotherapy.
  • Review of literature on NK cell biology and engineering advancements.
  • Analysis of clinical trials comparing NK cell therapies with CAR-T cell therapies.
  • Evaluating methodologies like genetic engineering, synthetic biology, and metabolic reprogramming.
  • Recent advancements have increased NK cell efficacy and specificity through genetic engineering techniques.
  • Preliminary clinical trials show NK cell therapies have promising efficacy and safety profiles in hematological cancers compared to CAR-T therapies.
  • Challenges remain with in vivo persistence and tumor infiltration, requiring further innovation.

Cite This Study

Sumit Sharma (2026) studied this question.

synapsesocial.com/papers/6a153a88b5d9c58d83e8d144https://doi.org/10.70389/pji.100010
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