Key result
Medical therapy withdrawal in idiopathic DCM linked to irreversible LVEF decline and cardiac fibrosis.
Why the study?
Does the withdrawal of medical treatments cause irreversible worsening of cardiac function and cardiac fibrosis in a patient with recovered dilated cardiomyopathy?
Case Report (n=1)
No
Does the withdrawal of medical treatments cause irreversible worsening of cardiac function and cardiac fibrosis in a patient with recovered dilated cardiomyopathy?
Withdrawal of heart failure medications in a patient with recovered dilated cardiomyopathy can lead to irreversible worsening of cardiac function and the development of replacement fibrosis.
Cautions against GDMT withdrawal in recovered DCM; hypothesis-generating for irreversible fibrosis.
A 44-year-old man diagnosed with idiopathic dilated cardiomyopathy was admitted to our hospital with acute decompensated heart failure. Seven years before this admission, the first introduction of medication resulted in left ventricular (LV) recovery, which was sustained for several years. However, the patient stopped taking his medication, resulting in worsening of the LV function. Despite the second introduction of medication, the LV function did not improve. We performed cardiac magnetic resonance imaging and an endomyocardial biopsy, which revealed the significant development of cardiac fibrosis that had not been present at the time of the initial diagnosis.
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Yazaki et al. (2020) conducted a case report in Idiopathic dilated cardiomyopathy (n=1). Withdrawal and reintroduction of medical treatments was evaluated on Left ventricular function and cardiac fibrosis. Withdrawal of medical treatment in a patient with idiopathic dilated cardiomyopathy led to irreversible worsening of left ventricular function associated with significant development of cardiac fibrosis.
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