Key result
Immunosuppressive treatment with prednisolone and azathioprine improved cardiac function and symptoms within 3 months in a patient with myocarditis-induced transition from hypertrophic to dilated cardiomyopathy.
Why the study?
Does immunosuppressive treatment improve cardiac function and symptoms in a patient with hypertrophic cardiomyopathy transitioning to a dilated phenotype due to active myocarditis?
Population
17-year-old female with known hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome presenting with…
Design
Case_report
Follow-up
3 months
Authors
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May support immunosuppression in biopsy-proven cases; leaves open confirmation in prospective studies before practice change.
Case Report (n=1)
Does immunosuppressive treatment improve cardiac function and symptoms in a patient with hypertrophic cardiomyopathy transitioning to a dilated phenotype due to active myocarditis?
External stress triggered by myocarditis can induce a reversible transition from a hypertrophic to a dilated cardiomyopathy phenotype, highlighting the diagnostic value of endomyocardial biopsy in unexplained heart failure.
Spillmann et al. (2015) conducted a case report in Hypertrophic cardiomyopathy transitioning to dilated cardiomyopathy due to active myocarditis (n=1). Immunosuppressive treatment (prednisolone and azathioprine) was evaluated on Improvement of cardiac function and symptoms. Immunosuppressive treatment with prednisolone and azathioprine improved cardiac function and symptoms within 3 months in a patient with myocarditis-induced transition from hypertrophic to dilated cardiomyopathy.
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