January 1, 1999Japanese Circulation Journal-english EditionOpen Access

Dynamic Outflow Obstruction due to Transient Extensive Left Ventricular Wall Motion Abnormalities Caused by Acute Myocarditis in a Patient With Hypertrophic Cardiomyopathy

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Why the study?

Does disopyramide improve dynamic outflow obstruction in a patient with hypertrophic cardiomyopathy and acute myocarditis?

Population

1 65-year-old woman with hypertrophic cardiomyopathy, liver cirrhosis with HCV, presenting with acute…

Design

Case_report

Follow-up

4 months

Authors

YSYasuhito Sakai YHYasushi HayashiWakayama Rosai Hospital YTYoshiaki TomobuchiWakayama Medical University

Discussion

Member takes

Implication

May support acute disopyramide for LVOTO relief in HCM-myocarditis; hypothesis-generating, needs prospective trials before practice change.

Structured PICO

Does disopyramide improve dynamic outflow obstruction in a patient with hypertrophic cardiomyopathy and acute myocarditis?

Population

1 65-year-old woman with hypertrophic cardiomyopathy, liver cirrhosis with HCV, presenting with acute pulmonary edema and dynamic LV outflow obstruction due to acute myocarditis.

Intervention

Disopyramide (25 mg intravenous initially, followed by 300 mg/day orally, later adjusted)

Outcome

Relief of dynamic outflow obstruction and pulmonary edemasurrogate

Disopyramide can effectively relieve dynamic LV outflow obstruction and pulmonary edema in patients with hypertrophic cardiomyopathy complicated by acute myocarditis.

Limitations

Provocation test for coronary artery spasm was not performed
Patient refused subsequent endomyocardial biopsy sampling
Causative virus was not determined

Cite This Study

Sakai et al. (1999) studied this question.

synapsesocial.com/papers/6a985f730c6adae875e33164 https://doi.org/10.1253/jcj.63.640

Topics

Hypertrophic cardiomyopathy Myocarditis Women and heart disease

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Implication

May support acute disopyramide for LVOTO relief in HCM-myocarditis; hypothesis-generating, needs prospective trials before practice change.

Dynamic Outflow Obstruction due to Transient Extensive Left Ventricular Wall Motion Abnormalities Caused by Acute Myocarditis in a Patient With Hypertrophic Cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Dynamic Outflow Obstruction due to Transient Extensive Left Ventricular Wall Motion Abnormalities Caused by Acute Myocarditis in a Patient With Hypertrophic Cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

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