Key result
Patients with hypertrophic cardiomyopathy exhibited impaired diastolic function, with a prolonged time constant of isovolumic relaxation (101 vs 51 ms; P<0.001) and increased chamber stiffness.
Why the study?
Are regional left ventricular mechanics, asynchrony, and asynergy altered in patients with hypertrophic cardiomyopathy compared to controls?
Population
22 patients with hypertrophic cardiomyopathy and 9 control subjects
Comparison
Assessment of regional mechanics, asynchrony… vs Control subjects
Design
Case-control
Authors
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Regional asynergy may drive diastolic impairment in HCM; extends nonuniformity observations but leaves open therapeutic implications.
Observational (n=31)
Are regional left ventricular mechanics, asynchrony, and asynergy altered in patients with hypertrophic cardiomyopathy compared to controls?
Absolute Event Rate: 101% vs 51%
p-value: p=<0.001
Hypertrophic cardiomyopathy is associated with impaired diastolic function driven by nonuniformity, hypertrophy, and regional asynergy with increased stiffness in myopathic regions.
Betocchi et al. (1993) conducted an observational in Hypertrophic cardiomyopathy (n=31). Hypertrophic cardiomyopathy vs. Control subjects was evaluated on Time constant of isovolumic relaxation (milliseconds) (p=<0.001). Patients with hypertrophic cardiomyopathy exhibited impaired diastolic function, with a prolonged time constant of isovolumic relaxation (101 vs 51 ms; P<0.001) and increased chamber stiffness.
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