Why the study?
Does acetazolamide improve subendocardial viability ratio and oxygen supply/demand ratio in healthy subjects during acute high-altitude exposure?
Population
44 healthy subjects (21 men, age range: 24-59 years)
Comparison
Acetazolamide 250 mg bid vs Placebo
Design
RCT, randomized, double-blind
Follow-up
3 days at high altitude
Key result
Acetazolamide attenuated the reduction in oxygen supply/demand ratio during acute high-altitude exposure compared to placebo (22.3 vs 17.3; P<0.001).
Authors
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Acetazolamide may mitigate hypoxia-related cardiac strain at altitude; extends RCT evidence to subendocardial oxygen indices in healthy subjects.
RCT (n=44)
Double-blind
randomized
Does acetazolamide improve subendocardial viability ratio and oxygen supply/demand ratio in healthy subjects during acute high-altitude exposure?
Absolute Event Rate: 22.3% vs 17.3%
p-value: p=<0.001
Acetazolamide may antagonize the reduction in subendocardial oxygen supply triggered by exposure to hypobaric hypoxia in healthy subjects.
Salvi et al. (2013) conducted an RCT in Healthy subjects exposed to high altitude (n=44). Acetazolamide vs. Placebo was evaluated on Oxygen supply/demand ratio at high altitude (p=<0.001). Acetazolamide attenuated the reduction in oxygen supply/demand ratio during acute high-altitude exposure compared to placebo (22.3 vs 17.3; P<0.001).