Why the study?
Does acetazolamide impair muscle endurance at sea level and simulated altitude?
Population
6 subjects, mean age 20+/-1 years
Comparison
Acetazolamide 250 mg orally three times a day… vs Placebo orally three times a day for 2 days
Design
RCT, double-blind
Follow-up
4 weeks
Key result
Acetazolamide impaired endurance performance at sea level (36 vs 48 min, P<0.05) but not at simulated altitude (20 vs 17 min, P=NS).
Authors
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Caution against acetazolamide for sea-level endurance exercise; extends evidence of altitude-specific performance preservation in this RCT.
RCT (n=6)
Double-blind
Does acetazolamide impair muscle endurance at sea level and simulated altitude?
Absolute Event Rate: 36% vs 48%
p-value: p=<0.05
Acetazolamide impairs endurance exercise performance at sea level but not at simulated altitude, likely because the resulting metabolic acidosis is offset by a ventilatory-induced increase in arterial oxygen saturation at altitude.
Fulco et al. (2006) reported an RCT. Acetazolamide vs. Placebo was evaluated on Endurance performance at sea level (minutes) (p=<0.05). Acetazolamide impaired endurance performance at sea level (36 vs 48 min, P<0.05) but not at simulated altitude (20 vs 17 min, P=NS).