What is the clinical evidence from this study?

Study design: Review. Population: Hypertension and Vascular Aging.

What question did this study set out to answer?

Investigate the impact of hypertension and aging on vascular changes and endothelial function.

May 9, 2017Current Hypertension ReviewsOpen Access

Microvascular Alterations in Hypertension and Vascular Aging

Q: What does this research mean for the field?

Activation of the renin-angiotensin-aldosterone and endothelin systems drives endothelial dysfunction and vascular remodeling in hypertension and aging via reactive oxygen species and inflammation. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

View Full Paper

Ask AI

Bookmark

Key result

Activation of renin-angiotensin-aldosterone and endothelin systems drives endothelial dysfunction and vascular remodeling in hypertension and aging via reactive oxygen species and inflammation.

Design

Review

Authors

CSCarmine SavoiaSapienza University of Rome ABA. BattistoniSapienza University of Rome VCValentin CalvezAgostino Gemelli University Polyclinic

Discussion

Member takes

Implication

Supports RAAS-endothelin modulation in hypertension; extends mechanistic insights but leaves open targeted trials in aging.

Key Points

Investigate the impact of hypertension and aging on vascular changes and endothelial function.
Described different hypertension phenotypes in younger and older subjects regarding vascular alterations.
Analyzed structural and functional changes in resistance and conduit arteries in relation to age and blood pressure levels.
Examined the roles of renin-angiotensin-aldosterone system and endothelin in endothelial dysfunction.
In younger individuals, early vascular alterations contribute to large artery stiffness, impacting outcomes.
In subjects over 50, conduit arteries show significant stiffness changes due to chronic high blood pressure.
Endothelial dysfunction correlates with increased reactive oxygen species, inflammation, and altered cell growth.

PICO

Population

Hypertension and Vascular Aging

Highlights the pathophysiological mechanisms of vascular remodeling and endothelial dysfunction in hypertension and aging, emphasizing the role of the renin-angiotensin-aldosterone and endothelin systems.

Cite This Study

Savoia et al. (2017) conducted a review in Hypertension and Vascular Aging. Activation of renin-angiotensin-aldosterone and endothelin systems drives endothelial dysfunction and vascular remodeling in hypertension and aging via reactive oxygen species and inflammation.

synapsesocial.com/papers/6a153f435347fbb1739f7831 https://doi.org/10.2174/1573402113666170505115010

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Microvascular Alterations in Hypertension and Vascular Aging

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

Topics

Microvascular Alterations in Hypertension and Vascular Aging

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

Also Consider

Topics

Also Consider