Key result
Direct visualization of single molecules revealed that two myosin heads are required to activate a thin filament regulatory unit, which can subsequently accommodate 11 additional myosins.
Direct single-molecule imaging demonstrates that two myosin heads are required to activate a thin filament regulatory unit, enabling cooperative binding of up to 11 additional myosins.
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Refines thin filament cooperativity models; leaves open translation to human cardiac contractility and disease.
Desai et al. (2014) studied Muscle contraction mechanism (in vitro). Fluorescent Myosin S1 was evaluated on Number of myosin heads required to activate a thin filament. Direct visualization of single molecules revealed that two myosin heads are required to activate a thin filament regulatory unit, which can subsequently accommodate 11 additional myosins.
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