May 8, 2017Scientific ReportsOpen Access

The molecular basis of thin filament activation: from single molecule to muscle

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Population

Single myosin molecule and single regulated actin thin filament

Design

Preclinical

Authors

TLThomas LongyearUniversity of Massachusetts Amherst SWSam WalcottWorcester Polytechnic Institute EDEdward P. DeboldHeart Failure / Cardiomyopathy

Discussion

Member takes

Implication

No immediate clinical implications; extends single-molecule evidence of cooperative thin filament activation.

Structured PICO

Population

Single myosin molecule and single regulated actin thin filament

Intervention

Calcium (Ca++) and myosin binding

Outcome

Effect of Ca++ on the rate of attachment of a single myosin molecule to a single regulated actin thin filament, and the distance over which myosin binding increases the attachment rate of neighboring moleculessurrogate

This study elucidates the distinct contributions of calcium and cooperative myosin binding to muscle thin filament activation at the single-molecule level.

Cite This Study

Longyear et al. (2017) studied this question.

synapsesocial.com/papers/6a952f5b77bd7906860f3a12 https://doi.org/10.1038/s41598-017-01604-8

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The molecular basis of thin filament activation: from single molecule to muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The molecular basis of thin filament activation: from single molecule to muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider