Key result
Troponin subunit gene regulation, alternative RNA splicing, and posttranslational modifications play central roles in modulating cardiac muscle contractility and adaptation in health and disease.
Design
Review
Authors
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Troponin regulation informs contractile adaptation in disease; leaves open isoform-specific therapies pending prospective validation.
This review highlights the critical roles of troponin isoform regulation, alternative splicing, and posttranslational modifications in cardiac development, function, and disease adaptation.
Sheng et al. (2014) conducted a review in Cardiac development and adaptation. Troponin subunit gene regulation, alternative RNA splicing, and posttranslational modifications play central roles in modulating cardiac muscle contractility and adaptation in health and disease.
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