Key result
Pacing deeper within the interventricular septum significantly improved pacing thresholds compared to proximal pacing (1.51 vs 5.2 V, P<0.001) and achieved intrinsic-like LV activation.
Absolute Event Rate: 1.51% vs 5.2%
p-value: p=<0.001
Pacing the peri-His region below the central fibrous body can achieve intrinsic-like LV activation patterns with acceptable pacing and sensing performance, potentially offering an alternative to direct His bundle pacing.
No takes yet. Share an insight, caveat, or question.
Deep septal pacing improves thresholds in animals; hypothesis-generating for human conduction-system pacing alternatives.
Laske et al. (2006) studied this question. Unipolar pacing in the interventricular septum vs. Different electrode depths (ED 1 vs ED 4) was evaluated on Pacing thresholds (p=<0.001). Pacing deeper within the interventricular septum significantly improved pacing thresholds compared to proximal pacing (1.51 vs 5.2 V, P<0.001) and achieved intrinsic-like LV activation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: