Thrombogenicity of Platinum–Chromium Everolimus- Eluting Stent Is Comparably Low to That of Cobalt– Chromium Everolimus-Eluting Stent in the Subacute Phase of Acute Myocardial Infarction

Takayuki Ishihara; Osamu Iida; Mitsutoshi Asai; Masaharu Masuda; Shin Okamoto; Kiyonori Nanto; Takashi Kanda; Takuya Tsujimura; Shota Okuno; Masaaki Uematsu; Toshiaki Mano

doi:10.15791/angioscopy.oa.20.0030

January 1, 2020AngioscopyOpen Access

Thrombogenicity of Platinum–Chromium Everolimus- Eluting Stent Is Comparably Low to That of Cobalt– Chromium Everolimus-Eluting Stent in the Subacute Phase of Acute Myocardial Infarction

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Key result

Platinum-chromium everolimus-eluting stents show comparably low thrombogenicity to cobalt-chromium everolimus-eluting stents in the subacute phase of acute myocardial infarction.

Why the study?

Subclinical intracoronary thrombus following implantation of CoCr-EES or PtCr-EES in AMI had not been explored.

Does platinum-chromium everolimus-eluting stent improve subclinical intracoronary thrombus compared to cobalt-chromium everolimus-eluting stent in patients with acute myocardial infarction?

Structured PICO

Does platinum-chromium everolimus-eluting stent improve subclinical intracoronary thrombus compared to cobalt-chromium everolimus-eluting stent in patients with acute myocardial infarction?

P

Population

42 patients (47 stents in 46 lesions) with acute myocardial infarction (AMI) who received staged percutaneous coronary intervention or follow-up coronary angiography 2 weeks after initial PCI. Mean age 64 ± 13 years, 90% male.

I

Intervention

Platinum-chromium everolimus-eluting stent (PtCr-EES) (21 stents in 20 patients)

C

Comparator

Cobalt-chromium everolimus-eluting stent (CoCr-EES) (26 stents in 22 patients)

O

Outcome

Degree of subclinical intracoronary thrombus adhesion and yellow plaque severity evaluated by coronary angioscopy at 13 ± 2 days after stent implantationsurrogate

Platinum-chromium everolimus-eluting stents demonstrate comparably low subclinical thrombogenicity to cobalt-chromium everolimus-eluting stents in the subacute phase of acute myocardial infarction.

Limitations

single-center, non-randomized, observational study with a small sample size
CAS cannot evaluate the entire stented segment
frequency of diabetes mellitus was different between CoCr-EES and PtCr-EES
relationship between degree of thrombus and future adverse clinical events was not clear

Implication

May not alter stent choice in subacute AMI; leaves open clinical outcome differences in randomized trials.

Abstract

Background: Population science has shown similar outcomes between cobalt–chromium everolimus-eluting stent (CoCr-EES) and platinum–chromium everolimus-eluting stent (PtCr-EES). However, subclinical intracoronary thrombus following implantation of CoCr-EES or PtCr-EES in acute myocardial infarction (AMI) has not been explored.

Discussion

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Cite This Study

Ishihara et al. (2020) studied this question. Platinum-chromium everolimus-eluting stents show comparably low thrombogenicity to cobalt-chromium everolimus-eluting stents in the subacute phase of acute myocardial infarction.

synapsesocial.com/papers/6a154190d73ae7522a4e2437 https://doi.org/10.15791/angioscopy.oa.20.0030

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Thrombogenicity of Platinum–Chromium Everolimus- Eluting Stent Is Comparably Low to That of Cobalt– Chromium Everolimus-Eluting Stent in the Subacute Phase of Acute Myocardial Infarction

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

Thrombogenicity of Platinum–Chromium Everolimus- Eluting Stent Is Comparably Low to That of Cobalt– Chromium Everolimus-Eluting Stent in the Subacute Phase of Acute Myocardial Infarction

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

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