Key result
AF in HF patients is linked to ~1.6 mL/kg/min lower VO2peak versus sinus rhythm.
Why the study?
Atrial fibrillation may exacerbate exercise intolerance and haemodynamic limitations in individuals with heart failure.
Does atrial fibrillation reduce peak oxygen uptake and exercise haemodynamics in patients with heart failure?
Meta-Analysis (n=6,471)
Does atrial fibrillation reduce peak oxygen uptake and exercise haemodynamics in patients with heart failure?
Effect estimate: WMD -1.55 mL/kg/min (95% CI -1.81 to -1.28)
In patients with heart failure, the presence of atrial fibrillation is associated with significantly worse exercise capacity (lower VO2peak) and impaired exercise hemodynamics compared to sinus rhythm.
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AF in HF may impair exercise capacity; extends meta-analytic quantification of VO2peak and hemodynamic deficits.
Schmid et al. (2024) conducted a meta-analysis in Heart failure (n=6,471). Atrial fibrillation vs. Sinus rhythm was evaluated on Peak oxygen uptake (VO2peak) (WMD -1.55 mL/kg/min, 95% CI -1.81 to -1.28). In patients with heart failure, atrial fibrillation was associated with significantly lower peak oxygen uptake compared to sinus rhythm (WMD -1.55 mL/kg/min; 95% CI -1.81 to -1.28).
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