Key result
The NYHA classification correlated inversely with 6MWD for classes II-IV, but showed significant heterogeneity and no significant difference in 6MWD between classes I and II (420m vs 393m; P=0.416).
Why the study?
Does the NYHA classification correlate with the 6-minute walk distance across different studies?
Population
37 studies involving 5,678 patients reporting both NYHA class and 6-minute walk distance (6MWD)
Comparison
New York Heart Association (NYHA) classification vs 6-minute walk distance (6MWD)
Design
Systematic_review
Authors
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NYHA I/II overlap cautions against sole reliance for mild HF stratification; challenges NYHA validity and supports objective measures in trials.
Systematic Review (n=5,678)
Does the NYHA classification correlate with the 6-minute walk distance across different studies?
The NYHA classification correlates well with 6MWD in more symptomatic patients (NYHA III/IV) but shows significant overlap and heterogeneity in asymptomatic or mildly symptomatic patients (NYHA I/II).
Yap et al. (2015) conducted a systematic review in Heart failure (n=5,678). NYHA classification vs. 6-minute walk distance (6MWD) was evaluated on Average 6-minute walk distance (6MWD) across NYHA classes. The NYHA classification correlated inversely with 6MWD for classes II-IV, but showed significant heterogeneity and no significant difference in 6MWD between classes I and II (420m vs 393m; P=0.416).
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