Key result
Atypical antipsychotics and SSRIs had a lower frequency of QTc prolongation than cilostazol (OR 0.43; 95% CI 0.27-0.69) and no significant difference versus diazepam (OR 0.89; 95% CI 0.55-1.47).
Why the study?
Do atypical antipsychotic drugs and SSRIs increase the risk of QTc prolongation compared to control drugs in clinical settings?
Population
Patients in an open-access QT database (ECG-ViEW)
Comparison
14 selected atypical antipsychotic drugs and… vs Positive control and negative control
Design
Cohort
Authors
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May not elevate QTc prolongation risk versus diazepam in real-world ECG data; leaves open randomized confirmation versus cilostazol.
Observational
Do atypical antipsychotic drugs and SSRIs increase the risk of QTc prolongation compared to control drugs in clinical settings?
Effect estimate: OR 0.43 (95% CI 0.27-0.69)
Atypical antipsychotics and SSRIs do not appear to significantly increase the risk of QTc prolongation compared to diazepam in a large clinical ECG database.
Park et al. (2016) conducted an observational in Patients taking atypical antipsychotics or SSRIs. 14 selected atypical antipsychotics and SSRIs vs. Cilostazol (positive control) and diazepam (negative control) was evaluated on Frequency of QTc prolongation (OR 0.43, 95% CI 0.27-0.69). Atypical antipsychotics and SSRIs had a lower frequency of QTc prolongation than cilostazol (OR 0.43; 95% CI 0.27-0.69) and no significant difference versus diazepam (OR 0.89; 95% CI 0.55-1.47).
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