Why the study?
Do psychotropic drugs prolong the QTc interval in older adults?
Population
8,222 adults aged ≥55 years from the Rotterdam Study who had triennial electrocardiograms.
Comparison
Psychotropic drugs, specifically starting… vs Participants not using the respective…
Design
Cohort
Follow-up
Triennial ECGs
Authors
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May warrant ECG monitoring with TCA initiation in older adults; leaves open arrhythmia risk and need for confirmatory trials.
Do psychotropic drugs prolong the QTc interval in older adults?
Starting tricyclic antidepressants or lithium is associated with a significant intraindividual increase in the QTc interval in older adults.
Noord et al. (2009) studied this question.
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