Key result
LBBB linked to ~340% higher risk of ventricular septal mid-wall fibrosis in patients with preserved LVEF.
Why the study?
Although LBBB is associated with ventricular septal mid-wall fibrosis in dilated cardiomyopathy, whether this association exists in patients with preserved LVEF remains unclear.
Is left bundle branch block associated with ventricular septal mid-wall fibrosis in hospitalized patients with preserved LVEF?
Observational (n=210)
Is left bundle branch block associated with ventricular septal mid-wall fibrosis in hospitalized patients with preserved LVEF?
Effect estimate: OR 4.399 (95% CI 1.774-10.904)
Absolute Event Rate: 58.3% vs 20.4%
p-value: p=0.001
In hospitalized patients with preserved LVEF, the presence of LBBB on a resting 12-lead ECG is strongly associated with ventricular septal mid-wall fibrosis detected by CMR.
LBBB-associated septal fibrosis on CMR should not yet change practice in preserved-LVEF inpatients; leaves open prognostic and therapeutic implications.
BACKGROUND: The left bundle branch block (LBBB) is associated with ventricular septal mid-wall fibrosis (SMF) in patients with dilated cardiomyopathy (DCM). However, whether LBBB is also associated with SMF in patients with preserved left ventricular ejection fraction (LVEF) remains unclear. METHODS: , I, and aVL). SMF determined by late gadolinium-enhancement cardiovascular magnetic resonance was defined as stripe-like or patchy mid-myocardial hyper-enhancement in the interventricular septal segments. RESULTS: SMF was detected in 24.8% (52/210) of these patients. The proportion of patients with SMF with LBBB was higher than the proportion of patients with SMF without LBBB (58.3% vs. 20.4%; P < 0.001). In the forward multivariate logistic analysis, LBBB (OR, 4.399; 95% CI, 1.774-10.904; P = 0.001) and age (OR, 1.028; 95% CI, 1.006-1.051; P = 0.011) were independently associated with SMF. The presence of LBBB showed a sensitivity of 27%%, specificity of 94%, positive predictive value of 58%%, and negative predictive value of 80% for the detection of SMF. CONCLUSION: LBBB was significantly associated with SMF in hospitalized patients with preserved LVEF. Screening with a resting 12‑lead ECG may help to identify patients who are at a high risk of the presence of SMF.
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Liu et al. (2024) conducted an observational in Preserved left ventricular ejection fraction (n=210). Left bundle branch block (LBBB) vs. Without LBBB was evaluated on Ventricular septal mid-wall fibrosis (SMF) (OR 4.399, 95% CI 1.774-10.904, p=0.001). Left bundle branch block was independently associated with ventricular septal mid-wall fibrosis in hospitalized patients with preserved LVEF (OR 4.399; 95% CI 1.774-10.904; P=0.001).
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