Key result
The incidence of mitral valve prolapse in patients with classical von Willebrand disease was 5.3%, comparable to the 6% incidence in the normal population, indicating no association.
Why the study?
Is there an association between mitral valve prolapse and von Willebrand disease?
Observational (n=19)
Is there an association between mitral valve prolapse and von Willebrand disease?
This study refutes previous claims of a high incidence of mitral valve prolapse in patients with von Willebrand disease, finding the rate to be similar to the general population.
The reported extremely high incidence of mitral valve prolapse in von Willebrand patients (60%) in combination with multiple signs of mesenchymal dysplasia points to a hitherto unknown pleiotropic effect of the von Willebrand gene and needs further confirmation. Therefore, we looked for the presence of mitral valve prolapse in 19 patients with classical von Willebrand disease. While 58% of these patients had one or more physical findings which could be interpreted as symptoms of mesenchymal dysplasia, we found only one patient with a mitral valve prolapse (5.3%), comparable to the 6% incidence in the normal population. Therefore, we must conclude that there is no association between mitral valve prolapse and von Willebrand disease.
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UHSEL et al. (2008) conducted an observational in von Willebrand disease (n=19). von Willebrand disease vs. normal population was evaluated on mitral valve prolapse. The incidence of mitral valve prolapse in patients with classical von Willebrand disease was 5.3%, comparable to the 6% incidence in the normal population, indicating no association.
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