Key result
A 3D simulation of the ischemic left ventricle successfully detected ventricular tachycardia, reentrant circuits, and wave fractionation under specific combinations of physiological parameters.
A 3D computational simulation of the ischemic left ventricle can model the conditions responsible for the formation of arrhythmias.
Answers are grounded in this paper and cite their sources.
Enables mechanistic exploration of ischemic VT; leaves open clinical translation pending validation.
A 3D simulation of the electrical activation map of the acute and chronic ischemic left ventricle (LV) is presented. The myocardial activation time maps and the signal propagation trajectories are determined by stipulating that the activation signals always propagate along the fastest possible trajectories. The high degree of nonhomogeneity of the physiological and electrophysiological tissue properties associated with the pathological ischemic LV is accounted for. The basic parameters are geometry and structure of the LV structural parameters on the macro level, distribution of the conduction speeds and refractory periods, effect of ischemia on the Purkinje and conduction networks, and details of ectopic activity. Ventricular tachycardia, reentrant circuits, and wave fractionation are detected when ectopic activity occurs at certain combinations of physiological parameters, demonstrating the potential of this 3-D simulation to determine the conditions responsible for the formation of arrhythmias.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
No takes yet. Share an insight, caveat, or question.
Bárta et al. (2003) studied Ischemic heart disease and arrhythmias. 3D simulation of electrical activation was evaluated on Detection of ventricular tachycardia, reentrant circuits, and wave fractionation. A 3D simulation of the ischemic left ventricle successfully detected ventricular tachycardia, reentrant circuits, and wave fractionation under specific combinations of physiological parameters.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: