Key result
In a computer model of anisotropic ventricular myocardium, heterogeneous activation and abnormal extracellular electrograms were directly related to the extent of cell-to-cell electrical disruption.
Why the study?
Does the degree of cellular uncoupling in a computer model of ventricular myocardium affect the inhomogeneity of activation and extracellular electrograms?
Does the degree of cellular uncoupling in a computer model of ventricular myocardium affect the inhomogeneity of activation and extracellular electrograms?
In a computer model of ventricular myocardium, greater cellular uncoupling directly correlates with increased inhomogeneity of activation and abnormal fractionated electrograms.
Model findings on uncoupling merit in vivo validation; leaves open translation to human arrhythmia mechanisms.
The implementation of a model of conduction in a heterogeneously uncoupled sheet of ventricular myocardium, with the pattern of uncoupling defined by a random, curdled fractal, is discussed. The authors tested the hypothesis that the greater the degree of cellular uncoupling, the greater the inhomogeneity of activation and the more abnormal the extracellular electrograms. They modeled propagation in a grid of resistively coupled cells. Resistors were assigned to produce a curdled pattern. A parameter relating the degree with which coupling resistance decorrelated with distance served to quantitate heterogeneous uncoupling. Heterogeneous activation and abnormal extracellular electrograms are directly related to the extent to which cell-to-cell electrical continuity is disrupted.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
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Lesh et al. (2002) studied Ventricular myocardium conduction (computer model). Heterogeneous cellular uncoupling (curdled fractal pattern) was evaluated on Inhomogeneity of activation and abnormality of extracellular electrograms. In a computer model of anisotropic ventricular myocardium, heterogeneous activation and abnormal extracellular electrograms were directly related to the extent of cell-to-cell electrical disruption.
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