Key result
Laminar myocardial sheet deformations account for ~90% of normal systolic wall thickening, with the magnitude of shortening/extension and shear increasing with preload and decreasing with afterload.
Population
Left ventricular myocardium
Design
Preclinical
Authors
Loading...
Does not alter clinical practice; extends animal data on load-dependent sheet mechanics in wall thickening.
The study demonstrates that laminar myocardial architecture undergoes substantial site- and load-dependent reorientation, which is essential for normal ventricular function throughout the cardiac cycle.
Takayama et al. (2002) studied Normal ventricular function and myocardial mechanics. Alterations in systolic and diastolic load was evaluated on Changes in systolic and diastolic function of the laminar sheets (reorientation, shortening/extension, and shear). Laminar myocardial sheet deformations account for ~90% of normal systolic wall thickening, with the magnitude of shortening/extension and shear increasing with preload and decreasing with afterload.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: